Supplement containing ECGC, resveratrol and Grape Seed Extract shown to work


If you were to consume 282 mg EGCG, 200 mg resveratrol, 92 mg Grape Seed Extract and 25 mg polyphenols from wed wine daily, you’d lose 3.4 kg fat in six months. In theory at least. Human biologists at the University of Maastricht will publish an article on this soon in the International Journal of Obesity.

If you were to consume 282 mg EGCG, 200 mg resveratrol, 92 mg Grape Seed Extract and 25 mg polyphenols from wed wine daily, you’d lose 3.4 kg fat in six months. In theory at least. Human biologists at the University of Maastricht will publish an article on this soon in the International Journal of Obesity.

If you were to consume 282 mg EGCG, 200 mg resveratrol, 92 mg Grape Seed Extract and 25 mg polyphenols from wed wine daily, you’d lose 3.4 kg fat in six months. In theory at least. Human biologists at the University of Maastricht will publish an article on this soon in the International Journal of Obesity.

The researchers did an experiment with nine healthy-but-on-the-heavy-side men, and nine women of similar proportions. The average BMI of the participants was 28. For three days the subjects took capsules containing phenols. On another occasion the subjects took placebo capsules for three days. They took the capsules with breakfast and the evening meal.

The researchers also experimented with a supplement containing not only EGCG, resveratrol and Grape Seed EGCG, but also soya isoflavones. The participants consumed 80 mg soya isoflavones per day.

On the third day of supplementation the researchers measured how many calories the subjects were burning. They measured energy expenditure when the subjects had not yet eaten [pre-meal] and after consuming a fat-rich meal replacement [post-meal].

The researchers discovered that the subjects burned 0.05 kilocalories per minute more before eating when they had taken the slimming supplement containing EGCG, resveratrol, Grape Seed Extract and wine phenols than when they had taken a placebo. Intriguingly, the effect of the supplement was much less when it contained soya isoflavones as well.

For the first six hours after eating, the supplement containing EGCG, resveratrol and Grape Seed Extract boosted energy expenditure by 0.02 kilocalories per minute. The supplement containing soya isoflavones had slightly more effect post-meal, boosting energy expenditure by 0.03 kilocalories per minute.

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The effects were subtle, but may be interesting in the longer term. If the subjects’ bodies had continued to react in the same way to the supplements, then after six months they would have lost 3.4 kg.

The study was financed by Alpro, a manufacturer of soya products.

Short-term supplementation with a specific combination of dietary polyphenols increases energy expenditure and alters substrate metabolism in overweight subjects.

Most J, Goossens GH, Jocken JW, Blaak EE.

Abstract

Background and Objectives:Impaired regulation of lipid oxidation (metabolic inflexibility) is associated with obesity and type 2 diabetes mellitus. Recent evidence has indicated that dietary polyphenols may modulate mitochondrial function, substrate metabolism and energy expenditure in humans. The present study investigated the effects of short-term supplementation of two combinations of polyphenols on energy expenditure (EE) and substrate metabolism in overweight subjects.Subjects and Methods:18 healthy overweight volunteers (9 women, 9 men; age 35±2.5?yrs; BMI 28.9±0.4?kg/m2) participated in a randomized, double-blind cross-over trial. Combinations of Epigallocatechin-gallate (E, 282?mg/d)+Resveratrol (R, 200?mg/d), and E+R+80?mg/d soy isoflavones (S), or placebo capsules (PLA) were supplemented twice daily for a period of 3 days. On day 3, circulating metabolite concentrations, energy expenditure and substrate oxidation (using indirect calorimetry) were measured during fasting and postprandial conditions for 6?h (high-fat-mixed meal (2.6?MJ, 61.2 E% fat)).Results:Short-term supplementation of E+R increased resting EE (E+R vs. PLA: 5.45±0.24 vs 5.23±0.25?kJ/min, P=0.039), whereas both E+R (699±18?kJ/120?min vs 676±20?kJ/120?min, P=0.028) and E+R+S (704±18?kJ/120?min vs 676±20?kJ/120?min, P=0.014) increased 2-4?h-postprandial EE compared with PLA. Metabolic flexibility, calculated as the postprandial increase to highest respiratory quotient (RQ) achieved, tended to be improved by E+R compared with PLA and E+R+S only in men (E+R vs PLA: 0.11±0.02 vs 0.06±0.02, P=0.059; E+R+S: 0.03±0.02, P=0.009). E+R+S significantly increased fasting plasma free fatty acid (P=0.064) and glycerol (P=0.021) concentrations compared with PLA.Conclusions:We demonstrated for the first time that combined E+R supplementation for 3 days significantly increased fasting and postprandial EE, which was accompanied by improved metabolic flexibility in men but not women. Addition of soy isoflavones partially reversed these effects possibly due to their higher lipolytic potential. The present findings may imply that long-term supplementation of these dosages of epigallocatechin-gallate combined with resveratrol may improve metabolic health and body weight regulation.International Journal of Obesity accepted article preview online, 9 December 2013. doi:10.1038/ijo.2013.231.

PMID: 24317366 [PubMed – as supplied by publisher]

Source: http://www.ncbi.nlm.nih.gov/pubmed/24317366

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