Your life expectancy grows, the more anabolic – and fewer catabolic – hormones your body produces. Researchers at Harvard Medical School reached this conclusion after performing a molecular-epidemiological study on 925 men and women over the age of 54.
The researchers used data that had been gathered in the Taiwanese Social Environment and Biomarkers of Aging Study. For that project scientists measured the concentration of the hormones IGF-1, DHEA and cortisol and the inflammatory protein interleukine-6 in the blood of 925 Taiwanese people. They also measured the length of the telomeres in DNA of the subjects’ white blood cells.
The shorter the telomeres, the shorter the amount of time you probably have left to live.
The less IGF-1 and DHEA they had in their body, the shorter the participants’ telomeres were. IGF-1 and DHEA are anabolic hormones. The relationships were not statistically significant, though.
The more cortisol they had in their body, the shorter the participants’ telomeres were. Cortisol is released in large quantities under conditions of physical and psychological stress, and has a catabolic effect. But this relationship was not statistically significant either.
The researchers then looked at the relationship between the anabolic hormones [IGF-1 and DHEA] and the catabolic cortisol [A/C imbalance summary]. The relationship between this ratio and the length of the telomeres was statistically significant.
Another relationship that proved to be statistically significant was the one between interleukine-6 [IL-6] – an inflammatory protein that is released in large quantities when you overtrain or are subject to psychological stress – and telomere length. The more IL-6 the subjects synthesised, the shorter their telomeres were. By the way, it was already known that increased synthesis of inflammatory proteins such as IL-6 and TNF-alpha decreases telomere length. [PLoS One. 2011;6(5):e19687.]
The more anabolic hormones your body produces, the longer you live. “In summary, in this population-based study of older Taiwanese adults, we found that high IL-6 levels were associated with short telomere length, and a higher A/C imbalance summary measure was associated with greater odds of having a short telomere length”, the researchers write. “Efforts to address anabolic and catabolic biochemical levels in clinical settings may contribute to our ability to detect the adverse health conditions associated with telomere length and potentially identify mechanisms to diminish and treat the consequences linked to these conditions.”
The researchers are concerned with people suffering from depression, but their results may also be of interest to athletes. Might athletes who over-train on a long-term basis be shortening their lives? And mightn’t interventions that reduce the synthesis of cortisol or boost the synthesis of anabolic hormones help extend athletes’ life expectancy?
Stress responsive biochemical anabolic/catabolic ratio and telomere length in older adults.
It has been hypothesized that chronic psychological stress is associated with shorter telomere length; however, the mechanisms that link stress and telomere length are not well understood. To examine the interplay between biochemical factors related to stress arousal and cellular aging, we investigate the association between anabolic/catabolic (A/C) imbalance and leukocyte telomere length (LTL) in the Social Environment and Biomarkers of Aging Study (SEBAS), conducted in Taiwan (N = 925). SEBAS participants aged 54 and older (mean age 68.3) with values for two anabolic hormones (serum dehydroepiandrosterone sulfate [DHEAS] and insulin growth factor [IGF]-1), four catabolic hormones (cortisol, epinephrine, norepinephrine, and interleukin-6 [IL-6]), and LTL were examined. We found that high IL-6 was associated with short LTL (? 0.88 T/S ratio; odds ratio [OR] 1.41, 95% confidence interval [CI] = 1.04-1.92). Neither DHEAS/cortisol nor IGF-1/cortisol ratio was associated with telomere length; however, a high A/C imbalance summary score was associated with greater odds of having a short LTL relative to long LTL (OR 1.19, 95% CI = 1.05-1.35). These results indicate that our A/C imbalance score, defined by several anabolic and catabolic biochemical factors, may be one mechanism through which psychological stress is associated with short LTL and possibly cellular senescence.
PMID: 25343365 [PubMed – in process]