Prevent heart attacks with Lycopene and beta-carotene

heart-attack

Men who eat lots of carrots and tomato juice are less likely to have a heart attack than men who don’t, according to an epidemiological study that Finnish epidemiologists published in the European Journal of Public Health. The Finns discovered that a high level of lycopene – a carotenoid found in tomatoes – and beta-carotene – a carotenoid found in carrots – protects against heart attacks.

Study
The researchers, who worked at the University of Eastern Finland, followed 1031 Finnish men aged 46-65 for 11.5 years. Before the study started the researchers measured the amount of lycopene, beta-carotene, alpha-carotene, retinol and alpha-tocopherol in the men’s blood.

Results
The men only found statistical correlations for lycopene and beta-carotene. The more lycopene and beta-carotene the men had in their blood, the less likely they were to have a heart attack.

In the figures below the researchers divided the men into three equal-sized groups according to the concentration of lycopene or beta-carotene in their blood. These groups are called tertiles. Tertile 1 = the men with the lowest concentration of lycopene or beta-carotene; tertile 3 = the men with the highest concentration. The steeper the downward curve, the more heart attacks.

1

Mechanism
The researchers suspect that lycopene and beta-carotene neutralise peroxyl compounds in the body. [Arch Biochem Biophys 2001;385:20–27.] [Arch Biochem Biophys. 1989 Nov 1;274(2):532-8.] In-vitro studies done in the 1990s suggest that lycopene in particular is a good oxygen catcher. The structural formula of lycopene is shown below.

2

Peroxyl compounds are free radicals. They have an oxygen atom that they want to get rid of. If they manage to attach that oxygen atom to LDL cholesterol, the oxidised cholesterol can damage blood vessel walls. Lycopene and beta-carotene both impede that process.

Conclusion
“This study demonstrated that low serum lycopene and beta-carotene concentrations may increase the risk of acute myocardial infarction in men”, the researchers wrote. “The results of this study support that the intake of foods rich in lycopene and beta-carotene may be considered to be useful in protecting from acute myocardial infarction.”

Low serum lycopene and ?-carotene increase risk of acute myocardial infarction in men.

Abstract

OBJECTIVE:
Previous studies have shown that high intake or concentrations of serum carotenoids may protect against acute myocardial infarction (AMI). The role of carotenoids on the risk of AMI remains inconsistent. The aim of the present study was to examine if serum concentrations of major carotenoids are related to AMI in men.

METHODS:
The study population consisted of 1031 Finnish men aged 46-65 years in the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids, retinol and ?-tocopherol were measured by high-performance liquid chromatography. The association between the serum concentrations of lycopene ?-carotene and ?-carotene and the risk of AMI was studied by using the Cox proportional hazard models.

RESULTS:
A total of 194 incident AMI cases occurred during an average of 11.5 follow-up years. After adjusting for potential confounders, the risk of AMI for men in the lowest tertile of serum concentrations compared with men in the highest tertile was 1.55 (95% CI 1.05- 2.30; P?=?0.028) for lycopene and 1.60 (95% CI 1.09-2.35; P?=?0.017) for ?-carotene.

CONCLUSIONS:
This cross-sectional study shows that low serum lycopene and ?-carotene concentrations may increase the risk of AMI in men.

PMID: 22158914 DOI: 10.1093/eurpub/ckr174 [PubMed – indexed for MEDLINE]

Source: https://www.ncbi.nlm.nih.gov/pubmed/22158914

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