Testofen: fenugreek extract that boosts men’s libido

In a couple of years fenugreek – Latin name: Trigonella foenum-graecum – may be a mainstream supplement like ginseng or ginkgo. You may have read the newspaper reports that fenugreek boosts men’s sexual appetite. [dailymail.co.uk 19th June 2011] We found the study that all the reports are based on, so can now reveal what’s in it. And what not.

Media make less and less news themselves, but are becoming expert in adopting each other’s stories. And that’s what happened with the minor media hype around the pro-sexual properties of fenugreek. The hundreds of web postings on the subject are all based on an article that was published on 19 June 2011 on the Daily Mail website. The article reported that men’s libido can increase by 28 percent if they take fenugreek.

Testofen: fenugreek extract that boosts men’s libido
“It probably works to increase testosterone or androgen levels, which decrease with age”, commented the British neurologist Raj Persad in the article. “If fenugreek is proven to be safe, this is good news. Men with good sexual health live longer than those without.”

The research that the Daily Mail based its article was published soon in Phytotherapy Research, and was done by researchers at the Australian company ASN Research. [www.asnresearch.com.au] The study does not say who commissioned the research, but one name is prominent: Gencor Pacific. Gencor is a company that sells raw materials for supplements for Indus Biotech. Indus Biotech is a big producer of fenugreek extracts – and supplied this for the Testofen that ASN Research tested.

The researchers gave their subjects a capsule each day containing 600 mg fenugreek extract, 17 mg magnesium, 15 mg zinc and 5 mg vitamin B6. This is a frequently used combination in fenugreek-based libido supplements.

The researchers gave 60 healthy men aged between 25 and 52, and with a normal sex life, a daily supplement or a placebo, for a period of six weeks. Before the test started and again after three and six weeks, the men had to say how often they thought of or fantasised about sex, how often they were sexually aroused, how often they had sex and how often they had an orgasm. The researchers used the DISF-SR questionnaire.

The figure below shows how much the total scores had risen after three weeks, and even more after six weeks. The table shows the effect of the supplement on the different aspects the researchers interviewed the subjects on.



The researchers are not sure exactly how fenugreek works. They measured the men’s testosterone and prolactin levels, but recorded no changes in these. The placebo group had a testosterone level of 14.6 nanomoles per litre at the start of the study. After six weeks this had gone down to 13.1 nanomoles per litre. The fenugreek group had a testosterone level of 14.8 nanomoles per litre at the start of the study and this went down to 14.3 nanomoles per litre.

The researchers do no mention what happened to the level of free testosterone. It’s strange that the researchers didn’t measure this. A popular theory suggests that fenugreek boosts the concentration of free testosterone.

Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation.


The aim of the clinical study was to evaluate the effect of Testofen, a standardized Trigonella foenum-graecum (Fenugreek) extract and mineral formulation, on male libido (sexual drive, urge or desire) in a double blind randomized placebo controlled study. The study recruited 60 healthy males aged between 25 and 52, without erectile dysfunction and randomized to an oral dose (two tablets per day) of the active treatment (600?mg Testofen per day) or placebo for 6?weeks. The primary outcome measure was the DISF-SR (male) self-administered QOL total score and the four domain scores. The secondary outcome was specific quality of life parameters. Testofen had an overall positive effect on physiological aspects of libido. In particular, there was a significant increase in the subdomains of sexual arousal and orgasm. Testofen had a positive effect on QOL in self-reported satisfaction with muscle strength, energy and well-being but did not have an effect on mood or sleep. Serum prolactin and testosterone levels remained within the reference range. It was concluded that Testofen demonstrated a significant positive effect on physiological aspects of libido and may assist to maintain normal healthy testosterone levels.
Copyright © 2011 John Wiley & Sons, Ltd.

PMID: 21312304 [PubMed – indexed for MEDLINE]

Source: http://www.ncbi.nlm.nih.gov/pubmed/21312304

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