MSM speeds up post-weight training recovery

MSM, full name methylsulfonylmethane, may be an interesting supplement for strength athletes. Sports scientist Douglas Kalman of the University of Memphis comes to this cautious conclusion after doing a small human study. According to the study, which was published in the Journal of the International Society of Sports Nutrition, it seems that a daily dose of 3 g MSM speeds up post-weight training recovery.

Everyday foods such as milk, fruit, coffee and tea provide us with small amounts of MSM. Studies have shown that this compound inhibits inflammation. MSM is believed to boost the production of the detoxifier glutathione, and to disrupt the nuclear factor kappa-beta. This is a transcription factor involved in the reaction of cells to nearly all kinds of stress – from UV radiation to LDL cholesterol, and from cancer to blood poisoning.

Intensive strength training stresses muscle cells and results in inflammation. The quicker the inflammation disappears, the faster the muscles recover. And you can guess what direction the researchers’ thinking took: whether MSM supplementation might help speed up muscle recovery.

The study was sponsored by TandemRain Innovations, George Bergstrom’s company. Bergstrom is also the driving force behind Bergstrom Nutrition [bergstromnutrition.com], the producer of the MSM preparation OptiMSM. This is the MSM that the researchers gave to their eight male subjects.

The researchers divided their subjects into two groups. One group were given a daily dose of 1.5 g MSM for 28 days; the other group were given 3 g MSM. Before and after the supplementation period the men trained their quadriceps by doing 18 sets on the leg extension machine.

Before, and then 2 and 48 hours after the training sessions, the researchers assessed the amount of muscle pain the subjects had and how tired they were. The figures below suggest that the 3 g dose of MSM certainly speeded up recovery.



MSM supplementation did not raise the amount of glutathione in the blood. It did raise the antioxidant activity in the blood two hours after the workout.


It’s not the first time that researchers have come across the protective effects of MSM on physical exertion. Researchers at the Islamic Azad University in Iran reported a few years ago that a 10-day supplementation period using 50 mg MSM per kg bodyweight reduced muscle damage after untrained men did endurance workouts. [J Pharm Pharmacol. 2011 Oct; 63(10): 1290-4.] [J Sports Med Phys Fitness. 2012 Apr; 52(2): 170-4.] In the Iranian studies MSM also boosted post-session antioxidant activity.

The American researchers are in favour of further research. “While this study was small in scope, it is suggested that more research be done to extend these findings”, they write. “Future studies should include a larger sample size, a placebo group for comparison and the inclusion of additional markers of recovery and exercise performance (e.g., force and power).”

In the autumn of 2012 Bergstrom Nutrition announced that it had developed a pre-workout application based on MSM and BCAAs in cooperation with Glanbia. [naturalproductsinsider.com October 25, 2012]

Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study.

Kalman DS, Feldman S, Scheinberg AR, Krieger DR, Bloomer RJ.


Department of Health and Sport Sciences, The University of Memphis, Cardiorespiratory/Metabolic Laboratory, 106 Roane Fieldhouse, Memphis, TN 38152, USA. rbloomer@memphis.edu.



Methylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in both animal and man. Strenuous resistance exercise has the potential to induce both inflammation and oxidative stress. Using a pilot (proof of concept) study design, we determined the influence of MSM on markers of exercise recovery and performance in healthy men.


Eight, healthy men (27.1?±?6.9 yrs old) who were considered to be moderately exercise-trained (exercising <150 minutes per week) were randomly assigned to ingest MSM at either 1.5 grams per day or 3.0 grams per day for 30 days (28 days before and 2 days following exercise). Before and after the 28 day intervention period, subjects performed 18 sets of knee extension exercise in an attempt to induce muscle damage (and to be used partly as a measure of exercise performance). Sets 1-15 were performed at a predetermined weight for 10 repetitions each, while sets 16-18 were performed to muscular failure. Muscle soreness (using a 5-point Likert scale), fatigue (using the fatigue-inertia subset of the Profile of Mood States), blood antioxidant status (glutathione and Trolox Equivalent Antioxidant Capacity [TEAC]), and blood homocysteine were measured before and after exercise, pre and post intervention. Exercise performance (total work performed during sets 16-18 of knee extension testing) was also measured pre and post intervention.


Muscle soreness increased following exercise and a trend was noted for a reduction in muscle soreness with 3.0 grams versus 1.5 grams of MSM (p?=?0.080), with a 1.0 point difference between dosages. Fatigue was slightly reduced with MSM (p?=?0.073 with 3.0 grams; p?=?0.087 for both dosages combined). TEAC increased significantly following exercise with 3.0 grams of MSM (p?=?0.035), while homocysteine decreased following exercise for both dosages combined (p?=?0.007). No significant effects were noted for glutathione or total work performed during knee extension testing (p?>?0.05).


MSM, especially when provided at 3.0 grams per day, may favorably influence selected markers of exercise recovery. More work is needed to extend these findings, in particular using a larger sample of subjects and the inclusion of additional markers of exercise recovery and performance.

PMID: 23013531 [PubMed] MCID: PMC3507661

Source: http://www.ncbi.nlm.nih.gov/pubmed/23013531

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