Ginsenoside-Rg1 in Panax ginseng protects athletes muscles

Supplementation with Panax ginseng – Chinese or Korean ginseng – may protect muscles against breakdown caused by intensive exercise. Biochemists at Taipei Physical Education College in Taiwan draw this conclusion from an animal study in which they gave rats the most important active substance in Panax ginseng. We’re not completely convinced yet, but a substance which in such small quantities has as much effect aginsenoside-Rg1 is of course always interesting.

Not all ginsengs are the same. The most important active substance in American ginseng or Ginseng quinquefolium, Ginsenoside-Rb1, for example has a relaxant and anti-androgenic effect, [Chin J Physiol. 2003 Mar 31;46(1):1-7.] ginsenoside-Rg1 in Panax ginseng a stimulatory and pseudo-oestrogenic effect. [Br J Pharmacol. 2009 Apr;156(7):1136-46.] The structural formula for ginsenoside-Rg1 is shown below.


Siberian ginseng is yet another story. In fact Siberian ginseng isn’t ginseng at all.

The Taiwanese study, which was published in the Journal of the International Society of Sports Nutrition, is about ginsenoside-Rg1. The study is part of a bigger project. The same researchers recently also published the results of a study in which they describe how supplementation with ginsenoside-Rg1 during extreme physical exertion had a protective effect on the liver of lab animals. [Evid Based Complement Alternat Med. 2012; 2012:932165.]

Ginsenoside-Rg1 is an interesting substance. In cell and animal studies it has been shown to boost the production of insulin receptors; it stimulates the creation of new blood vessels and wound healing; relaxes and widens blood vessels and lowers blood pressure. [Acta Pharmacol Sin. 2008 Sep; 29(9): 1103-8.]

The roots of Panax ginseng can contain anywhere between 0.17 and 0.27 percent ginsenoside-Rg1. That doesn’t sound like much, but the Taiwanese discovered that 0.1 mg per kg bodyweight is enough to have a strong effect. If you convert this quantity to the amount a human weighing 80 kg would need you arrive at 1.5 mg per day. To have that amount you’d only need several hundred milligrams of Panax ginseng per day.

The researchers gave their lab animals ginsenoside-Rg1 for a period of ten weeks and at the end of it got the animals to swim to the point of exhaustion. A control group was given no active substances. When the Taiwanese examined the rats’ muscles, and compared them with rats that hadn’t swum, they discovered that the supplementation boosted the activity of endogenous antioxidants.

The activity of some antioxidants, such as glutathione peroxidase [GPx], was raised during rest, which may have offered the rats some protection during the first phase of exercise. The activity of other antioxidants, such as glutathione S-transferase [GST], was raised when the researchers fished the animals out of the water.


Ginsenoside-Rg1 lowered the concentration of malondialdehyde [MDA] in the muscles of the rats that had swum. That suggests that the muscle membranes had incurred less damage. The supplementation had no effect on the concentration of protein carbonyl [PC], a marker for damaged proteins.

“The study suggests that Rg1 can be used to design nutraceutical supplements aimed to preserve normal biomolecular structure of skeletal muscle against exhaustive exercise-induced oxidative stress, which might be important in preventing loss of cellular function and warrants quick recovery after sports competition”, the Taiwanese conclude.

We suspect that the creation of such ‘nutraceutical supplements’ will require above all the efforts of production technologists. Much ginsenoside-Rg1 is lost in the traditional steaming process that is used to make ginseng-based preparations.

Oral Rg1 supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles.

Yu SH, Huang HY, Korivi M, Hsu MF, Huang CY, Hou CW, Chen CY, Kao CL, Lee RP, Lee SD, Kuo CH.

Laboratory of Exercise Biochemistry, Taipei Physical Education College, Taipei City, Taiwan. kuochiahua@gmail.com.



Previous studies reported divergent results on nutraceutical actions and free radical scavenging capability of ginseng extracts. Variations in ginsenoside profile of ginseng due to different soil and cultivating season may contribute to the inconsistency. To circumvent this drawback, we assessed the effect of major ginsenoside-Rg1 (Rg1) on skeletal muscle antioxidant defense system against exhaustive exercise-induced oxidative stress.


Forty weight-matched rats were evenly divided into control (N?=?20) and Rg1 (N?=?20) groups. Rg1 was orally administered at the dose of 0.1?mg/kg bodyweight per day for 10-week. After this long-term Rg1 administration, ten rats from each group performed an exhaustive swimming, and remaining rats considered as non-exercise control. Tibialis anterior (TA) muscles were surgically collected immediately after exercise along with non-exercise rats.


Exhaustive exercise significantly (p<0.05) increased the lipid peroxidation of control group, as evidenced by elevated malondialdehyde (MDA) levels. The increased oxidative stress after exercise was also confirmed by decreased reduced glutathione to oxidized glutathione ratio (GSH/GSSG ratio) in control rats. However, these changes were completely eliminated in Rg1 group. Catalase (CAT) and glutathione peroxidase (GPx) activities were significantly (p<0.05) increased by Rg1 in non-exercise rats, while no significant change after exercise. Nevertheless, glutathione reductase (GR) and glutathione S-transferase (GST) activities were significantly increased after exercise in Rg1 group.


This study provide compelling evidences that Rg1 supplementation can strengthen antioxidant defense system in skeletal muscle and completely attenuate the membrane lipid peroxidation induced by exhaustive exercise. Our findings suggest that Rg1 can use as a nutraceutical supplement to buffer the exhaustive exercise-induced oxidative stress.

PMID: 22607394 [PubMed]
PMCID: PMC3469378

Source: http://www.ncbi.nlm.nih.gov/pubmed/22607394

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