Beta-Alanine works better if you take it with meals


Athletes will benefit more and faster from a beta-alanine supplement [structural formula shown here, above] if they take the amino acid during meals. Sports scientists at Ghent University in Belgium discovered that taking the supplement during a meal leads to a faster increase in carnosine [structural formula shown here, below] concentration in the muscles than when it’s taken between meals.

The dipeptide carnosine neutralises the acids that are formed in the muscles during intensive physical exercise. The more carnosine there is in your muscle cells, the longer you can continue your exertions for. And that’s interesting for athletes.

The body makes carnosine by attaching the amino acids histidine and beta-alanine to each other. The body has an ample supply of histidine, but not of beta-alanine. That’s why beta-alanine supplementation is a good strategy for jacking up the carnosine levels in the muscle cells.

Muscle cells absorb creatine and L-carnitine better if you ingest them with food. After a meal, the concentrations of glucose, insulin and amino acids in the blood all rise. Your muscle cells absorb the substances and activate anabolic processes. If this helps the uptake of creatine and L-carnitine, is the same true for beta-alanine? That’s the question the Belgians set out to answer with their human study.

For a period of 46 days the researchers gave three groups of test subjects 3.2 mg beta-alanine every day. One group took their beta-alanine on four occasions throughout the day, between meals [PBA]. Another took their beta-alanine on three occasions at mealtimes throughout the day [PBA+Meal]. A third group used a slow release supplement containing beta-alanine, and took it 30 minutes before a meal.

Before the supplementation started and at the end of the experimental period, the researchers measured the concentration of carnosine in the gastrocnemius and soleus muscles of the test subjects. Taking the beta-alanine during mealtimes led to a greater increase in the carnosine concentrations in the muscle. When the subjects took their beta-alanine between meals, the amount of carnosine in their muscles rose by 40 percent. When they took the amino acid during meals, the amount of carnosine rose by 57 percent.

The uptake of the slow release version of beta-alanine taken half an hour before a meal was the same as when ordinary beta-alanine was taken during the meal. The meaning of this in practical terms escapes us, but it’s nice to know.



After taking beta-alanine, the concentration of beta-alanine in the blood rises. If the peak coincides with a higher insulin level, then muscle cells seem to absorb the amino acid better.

Several percent of the beta-alanine you take is lost through your urine. Only a small amount actually gets to the muscles. So where does the rest end up? “We suggest that beta-alanine oxidation could be an important metabolic fate of chronically ingested beta-alanine, possibly in skeletal muscle, but likely in other organs such as liver, kidney and brain”, the Belgians write. “However, it is not excluded that other metabolic pathways are involved as well.”

Meal and Beta-Alanine Coingestion Enhances Muscle Carnosine Loading.

Stegen S, Blancquaert L, Everaert I, Bex T, Taes Y, Calders P, Achten E, Derave W.


Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium 2Department of Endocrinology, Ghent University Hospital, Ghent, Belgium 3Department of Rehabilitation Sciences and Physiotherapy, Ghent University, Belgium 4Department of Radiology, Ghent Institute for Functional and Metabolic Imaging, Ghent University, Ghent, Belgium.



Beta-alanine (BA) is a popular ergogenic supplement as it can induce muscle carnosine loading. We hypothesize that, by analogy with creatine supplementation, 1) an inverse relationship between urinary excretion and muscle loading is present, and 2) the latter is stimulated by carbohydrate-and protein-induced insulin action.


In study A, the effect of 5 weeks slow-release BA (SRBA) supplementation (4.8g/day) on whole body BA retention was determined in 7 men. We further determined whether co-ingestion of carbohydrates and proteins with SRBA would improve retention. In study B (34 subjects), we explored the effect of meal-timing on muscle carnosine loading (3.2g/day during 6-7 weeks). One group received pure BA (PBA) in between the meals, the other received PBA at start of the meals, in order to explore the effect of meal-induced insulin release. Further, we compared with a third group receiving SRBA at start of the meals.


Orally ingested SRBA has a very high whole body retention (97-98%), that is not declining throughout the 5 weeks supplementation period, nor is it influenced by co-ingestion of macronutrients. Thus, a very small portion (1-2%) is lost through urinary excretion, and equally only a small portion is incorporated into muscle carnosine (~3%), indicating that the majority of ingested BA is metabolized (possibly through oxidation). Secondly, in soleus muscles, the efficiency of carnosine loading is significantly higher when PBA is co-ingested with a meal (+64%), compared to in between the meals (+41%), suggesting that insulin stimulates muscle carnosine loading. Finally, chronic supplementation of SRBA versus PBA seem equally effective.

PMID: 23439427 [PubMed – as supplied by publisher]