Beta Hydroxy-methylbuyrate (HMB)

Description:
HMB (beta-hydroxy-beta-methylbutyrate) is a metabolite of the amino acid leucine. HMB is found in the diet in small amounts in some protein-rich foods such as fish and milk. Depending on total protein and leucine intake, HMB production in the body may average about ¼ to 1 gram per day.

Claims:

Increased protein synthesis

Builds muscle

Decreased muscle breakdown

Prevents muscle catabolism

Increased strength

Enhanced fat burning

Theory:
HMB is thought to be the active form of leucine - an amino acid that plays a role in regulating protein metabolism. In theory, if you supply HMB as a supplement, you may be able to reduce muscle breakdown during intense exercise.

Scientific Support:
There is some evidence that HMB reduces muscle catabolism and may protect against muscle damage. For example, creatine kinase, an indicator of muscle damage, is reduced following exercise is subjects consuming HMB. This may indicate a reduced level of muscle damage and could lead to improved muscle function. Research in animals (cattle, pigs and poultry) and humans suggests that HMB can increase muscle mass and strength. Leucine is also a common additive to chicken feed (which is normally low in this amino acid) for the purpose of improving the muscle tissue and providing bigger chicken breasts for dinner

HMB has also been tested by NASA as a dietary approach to preventing the muscle wasting associated with prolonged spaceflight. Supplementation with 1.5-3.0 grams of HMB daily during weight training for 3 weeks increased muscle mass and strength and decreased the rise in exercise induced muscle damage. In one study, untrained subjects lifted weights for 4 weeks with or without 1.5 to 3 grams of HMB per day. The HMB supplements resulted in significant improvements in muscle mass and strength as well as significant decreases in muscle breakdown compared with placebo subjects. Even in trained athletes, HMB supplements of about 3 grams per day resulted in a significant increase in muscle mass and strength as well as a decrease in body fat.

One study looked at the effects of HMB supplements (as the calcium salt) on muscle breakdown (catabolism), strength and body composition during a resistance training program (7 hours per week for 4 weeks). Subjects were 40 experienced weight lifters who received either 3 or 6 grams per day of calcium HMB (or a placebo). Results showed that HMB supplementation resulted in a significant increase in blood levels of HMB, but no significant difference in muscle anabolic/catabolic status, lean body or fat mass, or overall muscle strength. Another study looked at HMB supplements (versus placebo) in 39 men and 36 women (aged 20-40 years). Subjects received 3 grams of HMB per day while training 3 times per week for 4 weeks. In the HMB group, blood levels of creatine phosphokinase (an indicator of muscle damage) were reduced compared to the placebo group, and both upper body strength and fat-free mass were increased. Overall, the study showed that a short-term period of HMB supplementation can increase upper body strength and minimize muscle damage when combined with an exercise program in both men and women.

Safety:
No side effects have been reported in animal studies (which have used large doses of HMB for several weeks) or in human studies of as much as 4 grams per day.

Value:
Athletes trying to minimize protein losses and muscle breakdown may want to consider HMB - particularly during very high intensity periods of training.

Dosage:
Recommended dose depends on training intensity - from 1 gram/day on rest days and easy days to about 3 grams on heavy training days.


References:
1. Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA, Rathmacher JA. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr. 2000 May-Jun;24(3):133-9. 2. Clarkson PM, Rawson ES. Nutritional supplements to increase muscle mass. Crit Rev Food Sci Nutr. 1999 Jul;39(4):317-28. 3. Kreider RB, Ferreira M, Wilson M, Almada AL. Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength. Int J Sports Med. 1999 Nov;20(8):503-9. 4. Kreider RB. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med. 1999 Feb;27(2):97-110. 5. Mero A. Leucine supplementation and intensive training. Sports Med. 1999 Jun;27(6):347-58. 6. Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC Jr, Connelly AS, Abumrad N. Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol. 1996 Nov;81(5):2095-104. 7. Nissen S, Sharp RL, Panton L, Vukovich M, Trappe S, Fuller JC Jr. beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr. 2000 Aug;130(8):1937-45. 8. Panton LB, Rathmacher JA, Baier S, Nissen S. Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (hmb) during resistance training. Nutrition. 2000 Sep;16(9):734-9. 9. Papet I, Ostaszewski P, Glomot F, Obled C, Faure M, Bayle G, Nissen S, Arnal M, Grizard J. The effect of a high dose of 3-hydroxy-3-methylbutyrate on protein metabolism in growing lambs. Br J Nutr. 1997 Jun;77(6):885-96. 10. Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med. 2000 Aug;30(2):105-16.

Added: September 6th 2002
Reviewer: SW Tech Staff
Related Link: Beta Hydroxy-methylbuyrate (HMB)
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