Lower oestrogen levels with physical activity

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The more you move, the less oestrogen circulates through your body. Biostatisticians at the University of Maryland published the results of a study they did in Medicine & Science in Sports & Exercise in which they discovered a relationship between oestrogen and activity after studying 452 women aged 40-72.

Study
The researchers fitted the participants with an accelerometer which they wore for seven days. This enabled the researchers to estimate how many minutes a day the women were moving or sitting still. The women were post-menopausal and not taking synthetic hormones.

At the end of the seven days the researchers measured the amount of estradiol and estradiol metabolites in the women’s urine. The urine concentrations correlate with the blood concentrations.

Results
The more movement the women had had (the higher the number of counts per minute registered by the accelerometers), the less estradiol and estrone the researchers found. So physical activity lowers the concentration of oestrogens in the body.

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Being sedentary has the opposite effect. The more minutes the women spent sitting each day, the more estradiol and oestrone there was in their urine, as you can see in the figure above.

How exercise reduces the amount of estradiol and oestrone is shown in the table below. Physical activity increased the ratio between the amount of metabolised – and therefore less active – analogues of estradiol and oestrone and the amount of non-metabolised estradiol and oestrone in the urine.

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Physical movement apparently activates the enzymes that metabolise – and neutralise – estradiol and oestrone. The figure below sketches the main processes involved in the metabolism of estradiol and oestrone.

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Conclusion
The researchers think that their findings are mainly of interest for women who want to reduce their likelihood of developing breast cancer, but these new insights are probably also relevant for men who want to reduce the levels of oestrogens in their body.

Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism.

Abstract

PURPOSE:
Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003).

METHODS:
Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy. Accelerometers, worn for 7 d, were used to derive measures of average activity (counts per day) and sedentary behavior (<100 counts per minute per day). Estrogen metabolites were measured in 12-h urine samples using liquid chromatography-tandem mass spectrometry. Estrogen metabolites were analyzed individually, in metabolic pathways (C-2, -4, or -16), and as ratios relative to parent estrogens. Geometric means of estrogen metabolites by tertiles of accelerometer-measures, adjusted for age and body mass, were computed using linear models.

RESULTS:
High activity was associated with lower levels of estrone and estradiol (P trend = 0.01), whereas increased sedentary time was positively associated with these parent estrogens (P trend = 0.04). Inverse associations were observed between high activity and 2-methoxyestradiol, 4-methoxyestradiol, 17-epiestriol, and 16-epiestriol (P trend = 0.03). Sedentary time was positively associated with methylated catechols in the 2- and 4-hydroxylation pathways (P trend ? 0.04). Women in the highest tertile of activity had increased hydroxylation at the C-2, -4, and -16 sites relative to parent estrogens (P trend ? 0.02), whereas increased sedentary time was associated with a lower 16-pathway/parent estrogen ratio (P trend = 0.01).

CONCLUSIONS:
Higher activity was associated with lower urinary estrogens, possibly through increased estrogen hydroxylation and subsequent metabolism, whereas sedentary behavior may reduce metabolism.

PMID: 26460631 PMCID: PMC4861700 [PubMed – in process]

Association of Active and Sedentary Behaviors with Postmenopausal Estrogen Metabolism.

Abstract

PURPOSE:
Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003).

METHODS:
Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy. Accelerometers, worn for 7 d, were used to derive measures of average activity (counts per day) and sedentary behavior (<100 counts per minute per day). Estrogen metabolites were measured in 12-h urine samples using liquid chromatography-tandem mass spectrometry. Estrogen metabolites were analyzed individually, in metabolic pathways (C-2, -4, or -16), and as ratios relative to parent estrogens. Geometric means of estrogen metabolites by tertiles of accelerometer-measures, adjusted for age and body mass, were computed using linear models.

RESULTS:
High activity was associated with lower levels of estrone and estradiol (P trend = 0.01), whereas increased sedentary time was positively associated with these parent estrogens (P trend = 0.04). Inverse associations were observed between high activity and 2-methoxyestradiol, 4-methoxyestradiol, 17-epiestriol, and 16-epiestriol (P trend = 0.03). Sedentary time was positively associated with methylated catechols in the 2- and 4-hydroxylation pathways (P trend ? 0.04). Women in the highest tertile of activity had increased hydroxylation at the C-2, -4, and -16 sites relative to parent estrogens (P trend ? 0.02), whereas increased sedentary time was associated with a lower 16-pathway/parent estrogen ratio (P trend = 0.01).
CONCLUSIONS:
Higher activity was associated with lower urinary estrogens, possibly through increased estrogen hydroxylation and subsequent metabolism, whereas sedentary behavior may reduce metabolism.

PMID: 26460631 PMCID: PMC4861700 [Available on 2017-03-01] DOI: 10.1249/MSS.0000000000000790 [PubMed – in process]

Source: https://www.ncbi.nlm.nih.gov/pubmed/26460631 

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