Joint Matrix Protocols – Rehabilitating Soft Tissue and Joints

Can hGH be used to heal damaged cartilage? It appears that pretty much any hard-core athlete worth the protein in a Snickers bar has or is experiencing the profound soft tissue pains their dedication to progress brings with the results. Regardless of age or body type, all except the weenies in Dolphin shorts at one time or another have had need to choose between pain relievers and progress…and/or sometimes simply giving up.Decrease Pain But Not A Cure

Some use one of the many specific COX-2 inhibitors (like Viox and Celebrex) or a non-specific COX inhibitor (such as Motrin) to reduce inflammation and subsequent pain. Others opt to employ Nubain or simply smoke a fatty. (The prior is not a cortisol inhibitor and the latter increases total estrogens due to structure. So blown or bitchy as a result of use) In either case, the use of a drug merely to mask the sensation of pain is in no way progress positive.

Growth Goodies For Joints?

Several studies have shown that GH and IGF-1 induce tissue growth within soft tissue and joints regardless of age. In fact, though most already know about GH/IGF-1 and permanent muscle tissue growth, few know that the long-term effects upon soft tissue are just as profound…if the right nutrients are available. (Huh?)

Diets Feed Joints Too!

Obviously diet is a crucial factor in over all health and athletic progress. In the case of soft tissue health, adequate supplies of vitamin A, B-6, C and of course E plus the minerals copper, zinc, selenium and manganese are mandatory. Joint tissues include the common collagen structures known as tendons, ligaments and cartilage. Synovial fluids act like oil to provide lubrication for smooth, comfortable motion. Vitamins A, C and E and selenium and zinc are antioxidants that perform specific joint tissue maintenance functions. Other antioxidants such as ALA can help also. If you are not getting at least the recommended daily intake (RDI) of the noted vitamins and minerals in your diet, you should be supplementing. A good multi-vitamin/mineral supplement should suffice.

Glucosamine

Glucosamine Sulfate is an amino sugar naturally produced by our bodies from glucose and sulfur. Sulfur is quite essential to healthy joints. It is in fact a major building and rebuilding component of ligaments, tendons and cartilage. Replacing lost or low production of glucosamine can help maintain, and in most cases, regenerate joint tissues…if the right hormone profile is created. Study after study, both abroad and in the US have shown dramatic regeneration of joint tissues and improved production of joint fluids with the use of glucosamine sulfate. Glucosamine Hydrochloride (HCI) is thought to offer more glucosamine per milligram than the sulfate. Both are easily absorbable.

Chondroitin

Chondroitin too is a natural component of cartilage and connective tissues. Studies have shown that Chondroitin Sulfate has similar effects in relation to glucosamine. (It goes without saying that the combination of chondroitin with glucosamine results in a more synergistic effect) An additional source of organic elemental sulfur is MSM (methylsulfonylmethane). MSM has been shown in other studies to aid in the production of collagen and glucosamine meaning a further potential synergist. My personal experience has been that 3g of glucosamine, 1.5g of chondroitin and 1-1.5g of MSM daily appears to be the maximal effective dosage.

Got A Dog?

An OTC veterinary product called Cosequin is one of the best glucosamine-chondroitin products available in my opinion. Most would assume that it is simply just another of many such products but it also contains a few cofactors that make it more effective. 4-6 caps daily provide an excellent soft tissue nutrient supply.

There are a number of treatments that can be used for soft tissue damage such as arthritis. In particular is the relatively new drug called Cartrophen Vet or pentosan (pentosan polysulphate sodium). This drug is one of the most effective and it even has a very good success rate in 8 out of every 10 dogs! Yup, another veterinary drug has been employed by athletes.

Pentosan can be administered subcutaneous, intramuscularly and locally. It appears to possess some very effectual direct anti-inflammatory activity. Due to its ability to inhibition lytic enzymes, and by increasing synovial fluid viscosity/volume, it acts synergistically with most other chemistry intended for soft tissue repair. Though this means preventative value, pentosan also significantly stimulates chondrocytes while increasing the biosynthesis of proteoglycans, as well as possessing strong fibrinolytic activity (joint matrix parts & pieces and repair activity).

*Though the drug pentosan is available in tablet form as well, my personal experiences have been that the use of the injectable form produces better results.

Nandrolone For Joints?

Almost anyone who has used nandrolone decanoate can attest to the profound increase in joint function and comfort. As a rule many AAS do have a positive effect upon joint function but nandrolone does so in a complementary way for rehabilitation. This is due to the increase in synovial fluid production that facilitates movement the way oil eases a door hinge. Naturally the increase in cellular protein synthesis in soft tissues is a nice plus as well.

Joint Matrix Protocol Example

Day
1. Nandrolone Decanoate 300mg/Pentosan 2ml/GH 2iu 3xd
2. GH 2iu 3xd
3. GH 2iu 3xd
4. GH 2iu 3xd
5. Nandrolone Decanoate 300mg/GH 2iu 3xd
6. Pentosan 2ml
7.
8. GH 2iu 3xd
9. Nandrolone Decanoate 300mg/ GH 2iu 3xd
10. GH 2iu 3xd
11. Pentosan 2ml/ GH 2iu 3xd
12. GH 2iu 3xd
13. Nandrolone Decanoate 300mg
14.
15. GH 2iu 3xd
16. Pentosan 2ml/ GH 2iu 3xd
17. Nandrolone Decanoate 300mg/ GH 2iu 3xd
18. GH 2iu 3xd
19. GH 2iu 3xd
20.
21. Nandrolone Decanoate 300mg/Pentosan 2ml
22. GH 2iu 3xd
23. GH 2iu 3xd
24. GH 2iu 3xd
25. Nandrolone Decanoate 300mg/ GH 2iu 3xd
26. Pentosan 2ml/ GH 2iu 3xd
27.
28.
29. Nandrolone Decanoate 300mg/ GH 2iu 3xd
30. GH 2iu 3xd
31. Pentosan 2ml/GH 2iu 3xd
32. GH 2iu 3xd
33. Nandrolone Decanoate 300mg/ GH 2iu 3xd
34.
35.
36. Pentosan 2ml/ GH 2iu 3xd
37. GH 2iu 3xd
38. GH 2iu 3xd
39. GH 2iu 3xd
40. GH 2iu 3xd
41. Pentosan 2ml
42.

*Aromasin 25mg/d or Arimidex 1mg/d

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References:

1. L S Phillips, J B Harp, S Goldstein, C I Pao Regulation and action of insulin-like growth factors at the cellular level Proceedings of the Nutrition Society , 49(3):451-458 1990
2. S Mohan, C Ribot Autocrine regulation of cell proliferation and secretion of insulin-like growth factor I (IGF-I) in osteoblastic cell line MC3T3-E1 ANNALES D ENDOCRINOLOGY , 55(2):95-102 1994
3. J Isgaard, A Nilsson, A Lindahl, J O Jansson, O G Isaksson Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats AMERICAN JOURNAL OF PHYSIOLOGY , 250(4 Pt 1):E367-E372 1986
4. Hertoghe T. Growth hormone therapy in ageing adults 4th Annual meeting of the American Academy of anti-aging Medicine, Las Vegas December 1996.
5. Bouillanne O, Rainfray M, Tissandier O et al. Growth hormone in elderly people:an age-delaying drug? Fundan Clin Pharmacol 1996 10 (5) 416-30.
6. Merimee TJ. Growth hormone secretion and action. Endocrinology DeGroot et al (eds) New York, NY 1979.
7. Thoren M, Hilding M, Baxter RR et al. Serum insulin like growth factor 1(IGF1), IGF binding protein -1 and -3 and the acid labile subunit as serum markers of body composition during growth hormone therapy in adults with GH
8. EVIDENCE-BASED ORTHOPAEDICS – Glucosamine and chondroitin were found to improve outcomes in patients with osteoarthritis JOURNAL OF BONE AND JOINT SURGERY , 82(9):1323 2000
9. The Role of Glucosamine Sulfate and Chondroitin Sulfates in the Treatment of Degenerative Joint Disease JOURNAL OF BONE AND JOINT SURGERY , 82(9):1323 000

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